Prospective roles for miRNAs during embryonic gonad development within the chicken
AMH sign transduction via the TGF-Я signalling path and involvement that is potential of.
AMH binds specifically into the AMH receptor (AMHR2), which activates either activin receptor 1 (ACVR1), or bone tissue morphogenic receptor 1A (BMPR1A), or 1B (BMPR1B). Activated ACVR1 and BMPR1A transduce AMH signals by activating SMAD signalling proteins (SMAD1, 5 or 8), with the assistance of ZEB1. BMPR1B competitively antagonises SMAD activation. (més…)